topoisomerase i — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T31011	Coralyne chloride		Topoisomerase
	Coralyne chloride is a protoberberine with strong anticancer activity. It can be used to prepare Coralyne derivatives, a fluorescent DNA-based molecular rectifier built into DNA duplexes through site-specific insertion. ...		Topoisomerase
T62002	Topoisomerase I inhibitor 7
	Topoisomerase I inhibitor 7 (Compound 8) is a potent inhibitor of Topoisomerase I. Topoisomerase I inhibitor 7 significantly inhibits tumor growth (up to 79%) and increases the lifespan (153%) of mice bearing P388 lympho...
T62225	Topoisomerase I inhibitor 8
	Topoisomerase I inhibitor 8, a hexacyclic analogue of camptothecin, is also a potent inhibitor of topoisomerase I and is toxic to tumour cells.
T80967	Topoisomerase I inhibitor 9		Topoisomerase
	Topoisomerase I Inhibitor 9 (compound 3d), a specific inhibitor of leishmanial topoisomerase IB, exhibits antileishmanial activity, demonstrating an IC50 value of 34.81μM against L. donovani promastigotes [1].		Topoisomerase
T60766	Topoisomerase I inhibitor 3
	Topoisomerase I (Compound ZML-14) inhibitor 3 induces HepG2 cell apoptosis and arrests cell cycle at G2/M phase. Topoisomerase I inhibitor 3 is an inhibitor of topoisomerase I that interact with topoisomerase I-DNA compl...
T80968	Topoisomerase I inhibitor 10		Topoisomerase
	Compound 13, a topoisomerase I inhibitor 10, selectively inhibits leishmanial topoisomerase IB and exhibits antileishmanial activity. Specifically, it demonstrates efficacy against L. donovani promastigotes with an IC50 ...		Topoisomerase
T61501	Topoisomerase I inhibitor 5
	Topoisomerase I inhibitor 5 is an efficient inhibitor of topoisomerase I, with an IC50 value. It effectively disrupts DNA and inhibits the activity of topoisomerase I. Moreover, it can induce apoptosis in MCF-7 cells and...
T60617	Topoisomerase I inhibitor 2
	Topoisomerase I inhibitor 2 (ZML-8) is a highly selective DNA topoisomerase I (Top1) inhibitor that inhibits Top1 activity and results DNA damage. Topoisomerase I inhibitor 2 blocks G2/M phase and induces apoptosis with ...
T61717	Topoisomerase I inhibitor 4
	Topoisomerase I inhibitor 4 (compound 7a) is a potent inhibitor of topoisomerase I activity. It effectively inhibits the proliferation of various cancer cell lines including HepG2, A549, MCF-7, and HeLa, with IC50 values...
T62094	Topoisomerase I inhibitor 6
	Topoisomerase I inhibitor 6 (Compound 3) is a potent inhibitor of Topoisomerase I that traps the DNA-Top1 cleavage complex and has low cytotoxicity in non-cancerous cell lines. Research value.
T61045	Topoisomerase I/II inhibitor 2
	Topoisomerase I/II inhibitor 2 (compound 1a) can significantly reduce the xenograft tumor growth in mice model which can be used in treating liver cancer. Topoisomerase I/II inhibitor 2 is a DNA topoisomerase I/II dual i...
T61990	Topoisomerase I/II inhibitor 3
	Topoisomerase I/II inhibitor 3 (compound 7) is a potent dual inhibitor of topoisomerase I (Topo I) and II (Topo II) . By inhibiting PI3K /Akt/mTOR signaling pathway, Topoisomerase I/II inhibitor 3 can inhibit cell prolif...
T63526	Topoisomerase I/II inhibitor 4
	Topoisomerase I/II inhibitor 4 is a potent dual inhibitor of topoisomerase I (Topo I) and II (Topo II) with inhibitory effects on cell proliferation, invasion and migration, and induction of apoptosis, and can be used to...
T1123	Camptothecin	NSC-100880,Campathecin,(S)-(+)-Camptothecin,CPT	Apoptosis , Influenza Virus , Topoisomerase , Antibiotic , Antifungal
	Camptothecin (CPT) belongs to the alkaloid group of natural products and is a specific DNA topoisomerase I (Topo I) inhibitor (IC50=679 nM) with specificity. Camptothecin has antitumor activity and induces apoptosis.
T17731	CL2A-SN-38		Others
	CL2A-SN-38 is a drug-linker conjugate consisting of SN-38, a potent DNA topoisomerase I inhibitor, and linker CL2A, for the manufacture of antibody drug conjugates (ADCs). CL2A-SN-38 provides significant and specific ant...		Others
TQ0134	Podocarpusflavone A		Topoisomerase
	Podocarpusflavone A is a DNA topoisomerase I inhibitor. It has moderated anti-proliferative activity induce cell apoptosis in MCF-7.		Topoisomerase
T6407	β-Lapachone	Beta-Lapachone,NSC-26326,SL-11001,ARQ-501	IDO , Apoptosis , Topoisomerase , Autophagy
	β-Lapachone (ARQ-501) is a specific DNA topoisomerase I inhibitor, and no inhibitory activities against DNA topoisomerase II or ligase.		IDO , Apoptosis , Topoisomerase , Autophagy
T21319	Gimatecan	LBQ707,STI481	Topoisomerase
	Gimatecan (STI481) is a potent topoisomerase I inhibitor. Gimatecan is an orally bioavailable camptothecin analogue with antitumor activity.		Topoisomerase
T60123	Chimmitecan	(S)-9-Allyl-10-hydroxycamptothecin	Topoisomerase
	Chimmitecan ((S)-9-Allyl-10-hydroxycamptothecin) is a potent inhibitor of topoisomerase I and displays outstanding activity in vitro and in vivo.		Topoisomerase
T21319L	Gimatecan HCl	ST1481 HCL,Gimatecan HCl(292618-32-7 Free base)	Topoisomerase
	Gimatecan HCl (ST1481 HCL) is a potent topoisomerase I inhibitor. Gimatecan is an orally bioavailable camptothecin analogue with antitumor activity.		Topoisomerase